论文部分内容阅读
目的:观察在常规西药治疗基础上加用小柴胡汤对提升慢性乙型肝炎患者肝功能、乙型肝炎病毒(HBV)-DNA拷贝数的影响。方法:纳入82例慢性乙型肝炎患者,随机均分为2组,对照组接受常规抗病毒、护肝降酶等治疗,观察组在对照组基础上联合应用小柴胡汤治疗。持续用药6月后,对比2组的肝功能、HBV-DNA变化及治疗应答率。结果:治疗后,2组谷草转氨酶(AST)、谷丙转氨酶(ALT)及总胆红素(TBil)均有下降,与治疗前相比,差异均有统计学意义(P<0.01);观察组上述指标值均低于对照组,差异均有统计学意义(P<0.01)。2组HBV-DNA拷贝数均较治疗前下降,差异均有统计学意义(P<0.01);观察组HBV-DNA拷贝数低于对照组,差异有统计学意义(P<0.01)。观察组治疗总应答率高于对照组,差异有统计学意义(P<0.05)。结论:小柴胡汤有助于提升常规治疗方案对慢性乙型肝炎的治疗效果,可提升患者的肝功能、降低HBV-DNA拷贝数。
OBJECTIVE: To observe the effects of Xiao Chai Hu Tang on improving liver function and hepatitis B virus (HBV) -DNA copy number in patients with chronic hepatitis B based on the conventional western medicine. Methods: Eighty-two patients with chronic hepatitis B were enrolled and randomly divided into two groups. The control group received conventional antiviral and hepatoprotective drugs. The observation group was treated with Xiao Chai Hu Tang on the basis of the control group. After 6 months of continuous administration, the liver function, HBV-DNA change and response rate of the two groups were compared. Results: After treatment, the levels of AST, ALT and TBil in both groups decreased, with statistical significance (P <0.01) The above index values were lower than the control group, the difference was statistically significant (P <0.01). The HBV-DNA copy number in the two groups was significantly lower than that before treatment (P <0.01). The HBV-DNA copy number in the observation group was lower than that in the control group (P <0.01). The total response rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). Conclusion: Xiao Chai Hu Tang can help to improve the curative effect of routine treatment on chronic hepatitis B, improve the liver function and reduce the copy number of HBV-DNA.