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抗菌药物治疗不仅会影响致病菌,而且影响肠内正常菌群。此外,抗菌药物的滥用导致肠道菌群在选择性压力作用下广泛传播其耐药性。一些研究已经揭示了使用抗菌药物后导致肠道菌群的紊乱,特别是一些菌群对抗菌药物敏感或者选择性耐药的问题。在人类肠道中,抗菌药物的使用可能导致耐药基因的长期存在。因此需要加强抗菌药物的管理,否则可能加剧新兴抗菌药物耐药菌株的形成。
Antimicrobial therapy will not only affect pathogens, but also affect the normal intestinal flora. In addition, the abuse of antimicrobial agents causes the gut flora to spread its drug resistance extensively under selective stress. Some studies have revealed the use of antibacterial drugs lead to intestinal flora disorders, in particular, some flora on the antimicrobial susceptibility or selective resistance problems. The use of antibacterials in human gut may lead to the long-term presence of resistant genes. Therefore, the need to strengthen the management of antibiotics, or may exacerbate the formation of new antibacterial drug-resistant strains.