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目的：探讨氨茶碱、环磷酸腺苷（ｃＡＭＰ）对膈肌疲劳的治疗作用。方法：实验用家兔双侧膈神经持续刺激，复制膈肌疲劳，分别给予氨茶碱１０ｍｇ／ｋｇ、ｃＡＭＰ１０ｍｇ／ｋｇ、氨茶碱１０ｍｇ／ｋｇ加ｃＡＭＰ１０ｍｇ／ｋｇ静脉注射，于药后３０ｍｉｎ、６０ｍｉｎ记录膈肌肌电图的中心频谱（Ｆｃ）、高低频比值（Ｈ／Ｌ）及膈肌诱发电位的振幅（Ａ）、潜伏期（Ｌ）。结果：氨茶碱、ｃＡＭＰ使疲劳膈肌的Ｆｃ、Ｈ／Ｌ、Ａ有一定提高，Ｌ值缩短；两者合用则作用显著。结论：氨茶碱、ｃＡＭＰ能影响膈肌的功能状态，对膈肌疲劳有治疗作用。两者合用，疗效更好
Objective: To investigate the therapeutic effect of aminophylline and cyclic adenosine monophosphate (cAMP) on diaphragmatic muscle fatigue. Methods: Experimental rabbits with bilateral phrenic nerve stimulation, diaphragmatic muscle duplication, were given aminophylline 10mg / kg, cAMP10mg / kg, aminophylline 10mg / kg plus cAMP10mg / kg intravenously, 30min, 60min after drug record The central electrocardiogram of the diaphragm (Fc), high and low frequency ratio (H / L) and diaphragm evoked potential amplitude (A), latency (L). Results: Aminophylline and cAMP increased the Fc, H / L and A of the fatigue diaphragm, while the L value shortened. The combined effect of aminophylline and cAMP was significant. Conclusion: Aminophylline and cAMP can affect the functional status of diaphragmatic muscle and have a therapeutic effect on diaphragmatic muscle fatigue. The two combined, better efficacy