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目的比较蒙古族、维吾尔族和汉族健康受试者单次静脉滴注盐酸多沙普仑后的药动学。方法蒙古族、维吾尔族和汉族健康受试者各10名,采用单次静脉滴注给药,用高效液相色谱法测定多沙普仑血药浓度,DAS 2.0软件程序计算药动学参数,并采用单因素方差分析对各民族受试者的药动学参数进行比较。结果多沙普仑在蒙古族、维吾尔族和汉族受试者体内的药动学参数AUC0-12、AUC0-∞和Cm ax具有显著性差异。男性与女性受试者的Vd有显著性差异。结论多沙普仑在蒙古族、维吾尔族和汉族健康受试者体内的药动学过程存在显著的民族差异,临床用药过程中应给予关注。
Objective To compare the pharmacokinetics of doxorubicin hydrochloride in Mongolian, Uigur and Han healthy subjects after a single intravenous infusion. Methods Ten Mongolian, Uygur and Han healthy subjects were enrolled in this study. Single intravenous drip infusion was used to measure plasma concentration of doxapram by high performance liquid chromatography. The pharmacokinetic parameters were calculated by DAS 2.0 software program. One-way analysis of variance (ANOVA) was used to compare the pharmacokinetic parameters of different ethnic groups. Results There was a significant difference in the pharmacokinetic parameters AUC0-12, AUC0-∞ and Cm ax among the Mongolian, Uygur and Han subjects. There was a significant difference in Vd between male and female subjects. Conclusion There is a significant ethnic difference in the pharmacokinetics of doxapram among Mongolian, Uygur and Han healthy subjects. Attention should be given to the clinical medication.