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家兔40只,分为治疗组(18只)、未治疗组(18只)及正常对照组(4只).未治疗组与治疗组家兔腹部皮下注射CCl_4溶液,造成肝损伤.治疗组在注射CCl_4后每日经口灌服人工引流熊胆粉120mg.治疗组和未治疗组分别于注射CCl_4后第1d、3d、6d、9d、12d、15d各扑杀3只,进行血液学、血清生化指标检测及肝脏病理组织学、组织化学与超微结构观察.结果:治疗组家兔血清中SGPT、γ—GT、LDH活性较未治疗组提前下降(P<0.01).治疗组与未治疗组治疗前后红、白细胞总数无显著差异(P>0.05).治疗组肝损伤的修复较未治疗组快.肝细胞内SDH、MAO、LDH及肝组织ATPase酶反应较未治疗组显著增强.
Forty rabbits were divided into treatment group (n = 18), untreated group (n = 18) and normal control group (n = 4) .The untreated and treated rabbits were injected subcutaneously with CCl_4 solution After the injection of CCl_4 daily oral administration of artificial drainage bear gall powder 120mg.The treatment group and the untreated group were injected with CCl_4 after 1d, 3d, 6d, 9d, 12d, 15d each cull 3, hematology, Serum biochemical detection and histopathology, histochemistry and ultrastructure were observed.Results: Compared with the untreated group, the activity of SGPT, γ-GT and LDH in the serum of the rabbits in the treatment group decreased in advance (P <0.01) The total number of red and white blood cells in the treatment group had no significant difference before and after treatment (P> 0.05), and the repair of liver injury in the treatment group was faster than that in the untreated group, and the activities of SDH, MAO, LDH and the activity of ATPase in liver tissue were significantly increased compared with the untreated group.