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目的:探讨血清CA125与子宫内膜异位症(EMs)的相关性。方法:对256例EMs患者进行回顾性分析。观察CA125与EMs分型、rAFS分期、痛经程度、子宫直肠窝封闭情况的关系。结果:①腹膜型EMs血清CA125水平显著低于卵巢型和混合型,卵巢型、混合型间差异无统计学意义;②不同临床分期间血清CA125差异均有统计学意义,期别越高血清CA125水平越高;③无痛经组血清CA125(19.5 KU/L)水平低于有痛经组(轻度:28.3 kU/L、中度:35.2 kU/L、重度:35.0 kU/L),差异有统计学意义,不同程度痛经组间血清CA125水平相当,差异无统计学意义;④子宫直肠窝无封闭组血清CA125水平显著低于部分或全部封闭组,差异有统计学意义,部分和全部封闭组血清CA125水平相当,差异无统计学意义;⑤各组间CA125的阳性率均有显著差异;⑥多因素非条件Logistic分析结果提示rAFS分期是血清CA125阳性的危险因素,分期越高血清CA125阳性的发生风险越高。结论:血清CA125对EMs病情严重程度的综合评估有重要意义,可用于协助判断EMs分型,临床上尤可用于EMs术前评价,为个体化术前处理提供参考。
Objective: To investigate the correlation between serum CA125 and endometriosis (EMs). Methods: 256 patients with EMs were retrospectively analyzed. The relationship between CA125 and EMs typing, rAFS staging, dysmenorrhea and uterine rectocele occlusion were observed. Results: ① The level of serum CA125 in peritoneal EMs was significantly lower than that in ovary and mixed type, and there was no significant difference between ovarian type and mixed type. ② The difference of serum CA125 between different clinical stages was statistically significant. The higher the level of serum CA125 ③ The level of serum CA125 (19.5 KU / L) in painless group was lower than that in dysmenorrhea group (mild: 28.3 kU / L, moderate: 35.2 kU / L, severe: 35.0 kU / L) Significance of different levels of dysmenorrhea serum CA125 levels were comparable, the difference was not statistically significant; ④ uterine rectal fossa without serum CA125 level was significantly lower than some or all of the closure group, the difference was statistically significant, partial and complete closure of serum (5) The positive rates of CA125 in each group were significantly different; (6) The results of multivariate non-conditional Logistic analysis suggested that the rAFS staging was the risk factor of serum CA125 positive, and the higher the staging was, the higher the serum CA125 positive occurred The higher the risk. Conclusion: Serum CA125 is of great significance for the comprehensive evaluation of the severity of EMs. It can be used to help determine the classification of EMs. It can be used clinically for the preoperative evaluation of EMs and provide a reference for individual preoperative treatment.