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目的：观察联用西咪替丁与云南白药治疗口服农药中毒致急性胃粘膜损害的疗效。方法：随机将口服各种农药中毒致急性胃粘膜损伤患者９０例，分为治疗组４６例和对照组４４例。治疗组在针对不同毒物品种的各自不同的综合治疗基础上，每日联用西咪替丁０．４～０．６ｇ加入５％葡萄糖５００ｍｌ静滴，并口服云南白药０．５０～０．７５ｇ（黑便者给１．０～１．５ｇ），每日３次。对照组每日给庆大霉素１６万～２４万Ｕ加入５％葡萄糖５００ｍｌ中静滴（呕血、黑便者同时口服０．００８％肾上腺素溶液）。结果：治疗组总有效率９７．９１％，对照组为４５．４５％。两组比较有非常显著性差异（Ｐ＜０．０１）。结论：西咪替丁通过阻断Ｈ２受体，使胃酸分泌减少，保护胃粘膜；云南白药可增加局部血流量，促进血小板聚集，增强吞噬细胞的吞噬能力，起到消肿、止痛、活血止血和祛腐生肌的目的，对急性胃粘膜出血患者止血快、疗效好。
Objective: To observe the curative effect of combined treatment of cimetidine and Yunnanbaiyao on acute gastric mucosal injury caused by oral pesticide poisoning. Methods: A total of 90 patients with acute gastric mucosal injury induced by various pesticide poisoning were randomly divided into treatment group (46 cases) and control group (44 cases). The treatment group in different poisonous drugs for different comprehensive treatment based on the daily combination of cimetidine 0.4 ~ 0.6g 5% glucose 500ml intravenous infusion of Yunnan Baiyao 0.50 ~ 0.75g (Black will give 1.0 ~ 1.5g), 3 times a day. In the control group, intravenous drip of gentamicin at 160,000-240000 U per day was given to 500 ml of 5% dextrose (hematemesis, melezone, 0.008% epinephrine orally at the same time). Results: The total effective rate was 97.91% in the treatment group and 45.45% in the control group. There was a significant difference between the two groups (P <0.01). Conclusion: Cimetidine can reduce gastric acid secretion and protect gastric mucosa by blocking H2 receptor. Yunnanbaiyao can increase local blood flow, promote platelet aggregation and enhance the phagocytic capacity of phagocytes, play a role in swelling, pain, blood circulation to stop bleeding And remove the rot myogenic purposes, the rapid bleeding of patients with acute gastric mucosal bleeding, good effect.