论文部分内容阅读
目的:总结造血干细胞移植过程中发生乳糜胸的治疗经验,并为异基因造血干细胞移植物中干细胞和过客淋巴细胞对植入的影响提供了现实依据。方法:报告1例原发耐药T淋巴母细胞淋巴瘤白血病患者行同胞全和异基因造血干细胞移植过程中发生损伤性大量乳糜胸的临床及治疗经过。结果:通过造血干细胞移植患者原发病获得了持续缓解,同时通过抽胸水、移植后早期胸腔镜下结扎胸导管等治疗手段,成功治疗了乳糜胸,并为移植早期发生乳糜胸淋巴液丢失对造血干细胞移植的影响积累了经验。结论:造血干细胞移植为部分原发耐药的T母细胞淋巴瘤患者提供了治愈机会;胸导管损伤供者淋巴细胞的丢失不影响移植物的植活;移植后早期微创手术的干预降低了大量乳糜胸的死亡率。
OBJECTIVE: To summarize the experience of treatment of chylothorax during hematopoietic stem cell transplantation and to provide a realistic basis for the effects of stem cells and passenger lymphocytes on allogeneic hematopoietic stem cell transplantation. Methods: The clinical and treatment of a large number of chylothorax lesions were reported in one patient with primary drug resistant T cell lymphoblastic leukemia undergoing sibling allogeneic allogeneic hematopoietic stem cell transplantation. Results: The patients were treated with hematopoietic stem cell transplantation for sustained remission. At the same time, chylothorax was successfully treated with pleural effusion and thoracoscopic thoracoscopic ligating thoracotomy. The impact of hematopoietic stem cell transplantation has accumulated experience. CONCLUSIONS: Hematopoietic stem cell transplantation provides a cure opportunity for some patients with primary T-cell lymphoma; the loss of lymphocytes from thoracic ductal injury donors does not affect graft engraftment; and the intervention of early minimally invasive surgery decreases Large chylothorax mortality.