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该研究拟从细胞水平观察地塞米松对感染CoxB-2病毒的人胚心肌细胞的作用效果。采用培养的人胚心肌细胞接种CoxB-2病毒,观察细胞生长、搏动情况及超微结构,测定心肌细胞释放的LDH(乳酸脱氢酶)活性。发现地塞米松治疗组的心肌细胞搏动较感染组者维持时间长,心肌细胞病变发展亦较缓慢,且LDH值明显低于感染组。说明地塞米松对感染CoxB-2病毒的人胚心肌细胞有明显的保护作用,提示临床上在重症病毒性心肌炎,特别是早期阶段,应用激素治疗能减轻心肌病变,对进一步的抢救病人有重要意义。
This study aimed to observe the effect of dexamethasone on human embryonic cardiomyocytes infected with CoxB-2 virus at the cellular level. Cultured human embryonic cardiomyocytes were used to inoculate CoxB-2 virus, cell growth, pulsation and ultrastructure were observed, and LDH (lactate dehydrogenase) activity released from cardiomyocytes was measured. Found that dexamethasone treatment group myocardial cell pulsation than the infected group for a long time, the development of myocardial cell disease is also more slowly, and the LDH value was significantly lower than the infected group. Dexamethasone on CoxB-2 virus infected human embryonic cardiomyocytes significant protective effect, suggesting that clinically in severe viral myocarditis, especially in the early stages, the application of hormone therapy can reduce myocardial lesions, for further rescue of patients is important significance.