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目的:研究毛鸡骨草对高脂血症大鼠血脂及血液流变学的影响。方法:采用高脂肪乳剂灌胃法复制大鼠高血脂模型,毛鸡骨草组连续给药21天后,采用全自动生化分析仪检测血脂的相关指标,采用全自动血液流变分析仪测定血液流变学指标。结果:毛鸡骨草组大鼠血清TC、TG的含量和全血粘度、全血还原粘度、卡松粘度和红细胞聚集指数、红细胞刚性指数、红细胞电泳时间、红细胞压积均较模型组明显降低,大鼠血清HDL含量则较模型组明显升高。结论:毛鸡骨草能降血脂并改变高血脂引起的血液流变学的变化,从而改善血液浓、粘、聚状态。
Objective: To study the effect of Abrus cantonii on blood lipids and hemorheology in hyperlipidemic rats. METHODS: Rat hyperlipidemia model was induced by intragastric administration of high fat emulsion. After 21 days of continuous administration in Maojigucao group, blood lipid parameters were measured using an automatic biochemical analyzer. Blood flow was measured by an automatic hemorheology analyzer. Change index. Results: The levels of TC, TG and whole blood viscosity, whole blood reduced viscosity, Casson viscosity and erythrocyte aggregation index, RBC rigidity index, red blood cell electrophoresis time, and hematocrit were significantly lower in the serum of the Abrus hirsutum group than in the model group. Serum HDL levels in rats were significantly higher than those in the model group. Conclusion: Abrus can reduce blood fat and change blood rheology caused by hyperlipidemia, thereby improving the state of blood thick, sticky and aggregate.