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运用短寿命T抑制细胞(TS)活性测定的方法分别检测了9例流产史孕妇和8例正常孕妇的TS细胞活性;同时在反应体系中分别加入流产史孕妇血浆和正常孕妇血浆,以观察其对TS活性的影响。结果发现流产史孕妇和正常孕妇的TS细胞本身的活性并无差别;同时发现流产史孕妇血浆有降低孕妇TS细胞活性的作用,推测流产史孕妇血浆中可能存在能降低孕妇TS细胞活性的特异和/或非特异的“抑制因子”,而作为对照的正常孕妇血浆有提高孕妇TS细胞功能的效应,推测正常孕妇血浆中可能存在能使孕妇TS细胞活性提高的特异和/或非特异的“刺激因子”。这提示,在其自身血浆的作用下,流产史孕妇的TS细胞活性降低可能是导致习惯性流产的原因之一。因本文例数尚少,以上结论有待进一步研究。
The TS cell activity of 9 pregnant women with miscarriage history and 8 normal pregnant women were detected by the method of measuring the activity of short-lived T-suppressor (TS) cells. At the same time, the plasma of pregnant women and normal pregnant women were respectively added to the reaction system to observe their TS activity Effect on TS activity. The results showed that the abortion history of pregnant women and normal pregnant women’s TS cell itself, there is no difference in activity; also found that abortion history of pregnant women to reduce the activity of TS cells in pregnant women, presumably miscarriage history of pregnant women may reduce TS activity in pregnant women specific and / Or non-specific “inhibitory factor”, whereas the normal pregnant women’s plasma as a control had the effect of improving TS cell function in pregnant women, suggesting that there may be specific and / or non-specific “stimuli” in the plasma of normal pregnant women that can increase TS cell activity in pregnant women factor". This suggests that reduced TS cell activity in pregnant women with abortion may be one of the causes of habitual abortion under the action of their own plasma. Due to the small number of cases in this article, the above conclusion needs further study.