凋零又称程序性细胞死亡,是细胞普遍具有的一种自我消亡机制,是细胞对外界信号刺激所作出的一种主动性死亡应答反应,是细胞的“自杀”。近年来的研究表明,凋零不但是正常生理性控制过程之一,同时也是化疗、放疗等抗肿瘤疗法杀伤瘤细胞的重要途径。因此,阐明凋零是否参与抗体交联物的细胞毒效应这一问题,对于深刻理解导向治疗的机理将具有重要的理论与实际意义。 Withering, also known as programmed cell death, is a self-destruction mechanism that cells generally have. It is an active death response response that the cells make to external signal stimulation and is the cell’s “suicide”. Recent studies have shown that withering is not only one of the normal physiological control processes, but also an important way to kill tumor cells by anti-tumor therapy such as chemotherapy and radiotherapy. Therefore, clarifying whether or not Fading is involved in the cytotoxic effect of antibody cross-links will have important theoretical and practical implications for a deep understanding of the mechanism of targeted therapy.