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自1968年以来哥伦布儿童医院在85户中发现了3户中的7个胞兄弟的Reye综合症(以下缩写RS),其发病率3,529/10万,比1974年流感B流行期间一般居民中0～18岁儿童的RS的发病率0.59/10万明显为高。承认并进一步研究RS的家族性将提供阐明此病的病因和病理机制,有助于确定遗传和环境因素在RS发展中的作用。本组7个孩子中有5人继发于水痘,2人继发于上感。在一个胞兄弟和另个胞兄弟中疾病发展的间隔是不同的,在C家与水痘同时出现而A家间隔到11天。
Rex syndrome (hereinafter referred to as RS) of 7 siblings of 3 households was found in 85 of the 85 Columbus Children’s Hospitals since 1968, with a prevalence of 3,529 per 100,000 compared to 0 in the general population during the 1974 influenza B epidemic The incidence of RS in children aged 18 years was significantly higher at 0.59 / 100,000. Recognition and further study of the familial nature of RS will provide elucidation of the etiology and pathology of the disease and will help determine the role of genetic and environmental factors in the development of RS. Five of the seven children in this group are secondary to chickenpox and two are secondary to the flu. In one sibling and another sibling, the intervals of disease development are different, with the simultaneous appearance of chickenpox in C and the interval of 11 days in A.