150～180克体重雌性大鼠口服含有0.5毫克norgestrel和0.05毫克ethinyloestradiol的Ovral-28口服避孕剂,每天100微克持续16天。于服完最后一剂的24小时后腹腔一次注射黄曲霉毒素B_1(AFB_1)3毫克。观察表明,未预服避孕剂大鼠的死亡率高;肝和血液中谷胱甘肽含量,于注射AFB_1后6和24小时分别降低51和38%;benzphetamine N-去甲基酶的专一活性减 Ovral-28 oral contraceptives containing 0.5 mg norgestrel and 0.05 mg ethinyloestradiol were orally administered to 150-180 g body weight female rats at 100 μg daily for 16 days. Aflatoxin B_1 (AFB_1) 3 mg was intraperitoneally injected 24 hours after the last dose of the service. The observation showed that the mortality of unprovoked contraceptive rats was high; the hepatic and blood glutathione levels were reduced by 51 and 38% at 6 and 24 hours after injection of AFB_1, respectively; the specific activity of benzphetamine N-demethylase Less