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了解大肠癌组织经东亚钳蝎毒灌肠前后，其ＤＮＡ参数的变化。方法对２０例大肠癌患者用东亚钳蝎毒灌肠治疗后，用ＣＭＩＡＳ真彩色医学图像分析系统测定肿瘤细胞核ＤＮＡ参数。结果１．ＤＮＡ指数均值（ＤＩ）治疗前为１．９２±０．１９，治疗后为１．５８±０．２４（Ｐ＜０．０１）。２．ＤＮＡ倍体在治疗后，≥５倍体者明显减少，二倍体明显增多（Ｐ＜０．０５）。３．细胞核面积的均值，核周长的均值和细胞浆面积均值在治疗后明显减少（Ｐ＜０．０５）。同期随机选１０例直肠癌患者用氟尿嘧啶灌肠，治疗前后各参数值虽有变化，但无统计学意义（Ｐ＞０．０５）。结论东亚钳蝎毒对大肠癌有抑杀作用，且优于氟尿嘧啶。
To understand the change of DNA parameters of colorectal cancer tissue before and after the clamp of East Asia. Methods Twenty patients with colorectal cancer were treated with Tocopherol-enhanced enema and the nuclear DNA parameters of tumor cells were measured with CMIAS true color medical image analysis system. Results 1. The average DNA index (DI) was 1.92±0.19 before treatment and 1.58±0.24 after treatment (P<0.01). 2. After the treatment of DNA ploidy, the patients with ≥5-ploidy were significantly reduced and the diploids were significantly increased (P<0.05). 3. The average of the nuclear area, the average of the nuclear perimeter and the mean cell area were significantly decreased after treatment (P<0.05). At the same time randomly selected 10 patients with rectal cancer with fluorouracil enema, although the parameters before and after treatment values change, but no statistical significance (P> 0.05). Conclusion The Toxicasteroderma can inhibit the colorectal cancer and is superior to fluorouracil.