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Wnt/β-Catenin(Wnt/β连结蛋白)信号通路已被证实参与脑肿瘤细胞和神经干细胞的信号表达,Wnt/β-Catenin信号通路抑制因子和部分胞浆组成成分能抑制细胞的增殖、分化、自我更新从而导致细胞凋亡和抑制肿瘤的生长。Wnt/β-Catenin信号的抑制作用为脑肿瘤的治疗方法和脑肿瘤干细胞的研究提供了一种新的途径。
The Wnt / β-Catenin (Wnt / β-Catenin) signaling pathway has been shown to be involved in the signal transduction of brain tumor cells and neural stem cells. Wnt / β-Catenin signaling pathway inhibitors and some cytosolic components can inhibit cell proliferation and differentiation , Self-renewal that leads to apoptosis and inhibits tumor growth. The inhibitory effect of Wnt / β-Catenin signaling provides a new approach for the treatment of brain tumors and the study of brain tumor stem cells.