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目的:探讨事件相关电位(P300)和额叶认知测试对帕金森病患者认知障碍评价的意义。方法:对31例非痴呆非抑郁帕金森病患者和25例年龄、性别、受教育程度相匹配的正常对照进行P300检测,同时采用词语流畅性、连线测验、Stroop字色干扰测验对病例组和对照组分别进行测试。结果:病例组与对照组比较:额叶认知功能评分较差,P300潜伏期延长(P<0.05),波幅下降;P300潜伏期与额叶认知功能障碍程度呈正相关。结论:非痴呆非抑郁帕金森病患者存在认知功能障碍。这种障碍可能是额叶功能受损后的表现。
Objective: To investigate the significance of event-related potentials (P300) and frontal lobe cognitive tests in the assessment of cognitive impairment in Parkinson’s disease patients. Methods: P300 was measured in 31 non-dementia non-depressive Parkinson’s disease patients and 25 normal controls with age, gender and educational attainment. At the same time, we used the word fluency test, connection test and Stroop test to examine the case group And control group were tested separately. Results: Compared with the control group, the score of cognitive function in frontal lobe was poor, the latency of P300 was prolonged (P <0.05), and the amplitude of P300 was decreased. The latency of P300 was positively correlated with the degree of cognitive impairment in frontal lobe. Conclusion: There is cognitive impairment in non-demented Parkinson’s disease patients. This disorder may be the performance of the frontal lobe impaired.