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背景:胰岛素瘤是最常见的胰腺内分泌肿瘤。Ki-67作为一种细胞增殖标志,与多种肿瘤的分化、浸润、转移和预后密切相关。目的:研究Ki-67在胰岛素瘤中的表达情况,探讨其作为胰岛素瘤良恶性鉴别和预后判断标志物的可能性。方法:选取45例胰岛素瘤组织和9例配对瘤旁正常胰腺组织,以免疫组化方法检测Ki-67的表达,并分析其表达与胰岛素瘤临床病理特征的关系。结果:45例胰岛素瘤组织中18例Ki-67表达阳性,阳性率为40.0%,9例配对瘤旁正常胰腺组织均不表达Ki-67。5例(11.1%)胰岛素瘤组织Ki-67指数≥2%。除术前血糖<2.8mmol/L者Ki-67表达阳性率显著低于术前血糖≥2.8mmol/L者(P=0.025)外,Ki-67表达阳性与否和Ki-67指数与胰岛素瘤的临床病理特征,包括性别、年龄、症状出现至确诊时间、肿瘤原发部位、大小、是否多发、良恶性、有无转移和术后是否治愈均不相关。结论:根据本研究结果尚不能确定Ki-67能作为鉴别胰岛素瘤良恶性和预后判断的标志物。
Background: Insulinomas are the most common pancreatic endocrine tumors. Ki-67 as a marker of cell proliferation, and a variety of tumor differentiation, invasion, metastasis and prognosis are closely related. OBJECTIVE: To study the expression of Ki-67 in insulinoma and to explore its potential as a marker of benign and malignant differentiation and prognosis of insulinoma. Methods: 45 cases of insulinoma tissue and 9 cases of paracancerous normal pancreatic tissue were selected to detect the expression of Ki-67 by immunohistochemistry. The relationship between the expression of Ki-67 and the clinicopathological features of insulinoma was analyzed. Results: Ki-67 was positive in 18 cases of 45 insulinoma tissues and the positive rate was 40.0%. Ki-67 index of Ki-67 in Ki-67.5 cases (11.1%) was not found in all 9 cases of paracancerous normal pancreatic tissues ≥2%. In addition to the preoperative blood glucose <2.8mmol / L Ki-67 expression was significantly lower than preoperative blood glucose ≥ 2.8mmol / L were (P = 0.025), Ki-67 positive or not and Ki-67 index and insulinoma The clinical and pathological features, including gender, age, symptoms to the time of diagnosis, the primary tumor site, size, whether multiple, benign and malignant, with or without metastasis and postoperative cure are not related. Conclusion: According to the results of this study, it is uncertain that Ki-67 can be used as a marker to differentiate malignant and malignant prognosis of insulinoma.