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目的研究儿童非综合征型总唇裂发生的主要环境影响因素,为预防其发生提供相关分析数据。方法采用以医院为基础的病例对照研究方法,对非综合征型总唇裂病例和对照的母亲进行问卷调查,应用SPSS13.0统计软件包对资料进行单因素分析和多因素非条件logistic回归分析。结果多因素分析结果显示:叶酸(OR=0.100,95%CI:0.032～0.312)有可能预防非综合征型总唇裂的发生;感染(OR=4.155,95%CI:2.166～7.970)、化学毒物接触(OR=6.816,95%CI:2.528～18.381)、情绪状况(OR=3.250,95%CI:1.477～7.154)是引起非综合征型总唇裂发生的危险因素。结论母亲妊娠早期感染、妊娠早期化学毒物接触和心情紧张是影响儿童非综合征型总唇裂的主要危险因素,加强妊娠早期叶酸的补充有可能降低发病的风险。
Objective To study the main environmental factors affecting the total cleft lip in children with non-syndromic syndrome and to provide relevant analysis data for the prevention of its occurrence. Methods A hospital-based case-control study was conducted to investigate the non-syndromic cleft lip and the control mothers. Univariate analysis and multivariate non-conditional logistic regression analysis were performed using SPSS 13.0 statistical package. Results The results of multivariate analysis showed that folic acid (OR = 0.100, 95% CI: 0.032-0.312) could prevent the occurrence of nonsyndromic cleft lip. Infection (OR = 4.155, 95% CI: 2.166-7.970) (OR = 6.816, 95% CI: 2.528-18.381). Emotional status (OR = 3.250, 95% CI: 1.477-7.154) was the risk factor of total cleft lip with nonsyndrome. Conclusion Early maternal infection, early pregnancy exposure to chemical toxins and stress are the major risk factors affecting non cleft lip in children. Strengthening the folic acid supplementation in early gestation may reduce the risk of morbidity.