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前列腺癌(PCa)是目前男性常见的肿瘤之一,且发病率逐年上升,是欧美男性第2高病死率的疾病。其肿瘤标志物:总前列腺特异抗原(t PSA)的应用,显著提高了PCa的检出率,致手术后患者转移率及病死率降低。此外,t PSA检测的特异性目前尚不十分理想[1]。由于前列腺所有上皮细胞,不论正常的、增生的还是癌细胞,均会合成分泌t PSA,所以其t PSA升高并非仅由PCa引起。良性前列腺增生(BPH)感染、急慢性前
Prostate cancer (PCa) is one of the common tumors in men and the incidence is increasing year by year. It is the second highest case fatality rate in Europe and the United States. Its tumor marker: Total Prostate Specific Antigen (t PSA), significantly increased the detection rate of PCa, resulting in postoperative surgical patients and mortality reduction. In addition, t PSA detection specificity is not yet very good [1]. Since all epithelial cells of the prostate, whether normal, hyperplastic or cancerous, synthesize and secrete t-PSA, their elevated t PSA is not solely due to PCa. Benign prostatic hyperplasia (BPH) infection, acute and chronic