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一、胃粘膜屏障(一)胃粘膜屏障定义和功能正常胃壁组织间液的H~+浓度为0.00005毫当量/升,胃腔的H~+浓度为150～170毫当量/升,两者H~+浓度相差约300万倍.从H~+梯度考虑,胃粘膜应受到胃酸侵蚀,然而正常胃粘膜具有对抗H~+侵蚀的能力.1964年Darenport提出正常胃粘膜能阻止氢离子从胃腔向胃粘膜内扩散,并阻止钠离子从粘膜细胞间隙向胃内扩散,这种只允许氢离子及钠离子各向一定方向通行,对抗H~+的侵蚀功能称之为胃粘膜屏障.这种功能一方面防止胃液的自身消化,另一方面使胃腔内盐酸适合食物消化的需要.
I. Gastric Mucosal Barrier (I) The definition and function of the gastric mucosal barrier The normal concentration of H~+ in the interstitial fluid of the stomach wall is 0.00005 milliequivalents/liter, and the concentration of H~+ in the gastric lumen is 150 to 170 milliequivalents/liter. The difference between ~+ concentrations is about 3 million times. From the perspective of H~+ gradient, gastric mucosa should be eroded by gastric acid, whereas normal gastric mucosa has the ability to resist H~+ erosion. In 1964 Darenport proposed that normal gastric mucosa can prevent hydrogen ions from the stomach cavity. It diffuses into the gastric mucosa and prevents the diffusion of sodium ions from the intercellular space into the stomach. This allows only hydrogen ions and sodium ions to pass in a certain direction. The erosion function against H~+ is called the gastric mucosal barrier. Function on the one hand to prevent the self-digestion of gastric juice, on the other hand so that the stomach cavity hydrochloric acid for food digestion needs.