论文部分内容阅读
目的观察Ki67在不同的宫颈病变中的表达情况。方法采用免疫组织化学S-P检测法,检测宫颈组织石蜡包埋标本108例(LCIN22例、HCIN22例和SC64例)Ki67的蛋白表达状况。结果 Ki67抗原的表达强度从LCIN组、HCIN组到SC组逐渐增强,呈正相关(Gamma=0.391,P<0.01)。在SC组中,Ki67的阳性表达率与患者的年龄、组织学分级和临床分期均无相关性。结论随着病变级别的升高(从LCIN、HCIN到SC),Ki67的表达趋势是逐渐升高的,提示它可能在宫颈癌的发展的过程中起重要作用,可作为预测CIN转归的指标。Ki67,可能是宫颈癌早期诊断的重要标记物。
Objective To observe the expression of Ki67 in different cervical lesions. Methods Immunohistochemical S-P method was used to detect the protein expression of Ki67 in 108 cases of cervical tissue specimens (22 cases of LCIN, 22 cases of HCIN and SC64 cases). Results The expression intensity of Ki67 antigen increased gradually from LCIN group to HCIN group to SC group (Gamma = 0.391, P <0.01). In SC group, Ki67 positive expression rate and patient’s age, histological grade and clinical stage have no correlation. Conclusions The expression of Ki67 is gradually increased with the increase of the lesion level (from LCIN, HCIN to SC), suggesting that it may play an important role in the development of cervical cancer and may be used as an index to predict the outcome of CIN . Ki67, may be an important marker of early diagnosis of cervical cancer.