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为了研究肝源性溃疡病(HPU)的临床、内镜特征及其可能的发病机理,本文研究了164例慢性肝病患者及36例急性肝炎患者的内镜结果与临床特征,探讨HPU患者血清微量元素变化。结果:HPU患病率为46.9％,其中十二指肠球部溃疡占88.3％,平均发病年龄46.8岁,临床症状不典型;HPU患病率与肝脏病变程度呈正相关;HPU患者血清Zn明显降低(P<0.05),Fe轻度增加。结论:HPU不同于普通消化性溃疡;其发病机理不完全清楚,可能是与肝病有关的攻击因子增强及防御因子减弱多因素共同作用的结果。
In order to study the clinical and endoscopic features of HPU and its possible pathogenesis, we studied the endoscopic findings and clinical features of 164 patients with chronic liver disease and 36 patients with acute hepatitis, Element changes. Results: The prevalence of HPU was 46.9%, of which the duodenal ulcer accounted for 88.3% with an average age of 46.8 years. The clinical symptoms were not typical. The prevalence of HPU was positively correlated with the degree of liver disease. The serum Zn of HPU patients was significantly lower (P <0.05), Fe increased slightly. Conclusion: HPU is different from ordinary peptic ulcer; the pathogenesis of HPU is not completely understood, which may be the result of multifactorial combination of enhancement of attack factors associated with liver disease and reduction of defensive factor.