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目的探讨巨噬细胞抑制因子-1(Macrophage inhibitory cytokine-1,MIC-1)在老年晚期非小细胞肺癌中表达与病理特征的相关性。方法用免疫组化法检测60例老年晚期非小细胞肺癌组织MIC-1的表达,并进行临床病理因素相关性分析。结果 MIC-1在老年晚期非小细胞肺癌组织表达,阳性表达率与临床分期相关。结论 MIC-1可作为评价老年晚期非小细胞肺癌发生、发展的生物学指标,为寻找老年晚期非小细胞肺癌新的治疗手段提供依据。
Objective To investigate the correlation between the expression of macrophage inhibitory cytokine-1 (MIC-1) and pathological features in advanced non-small cell lung cancer. Methods Immunohistochemistry was used to detect the expression of MIC-1 in 60 elderly patients with advanced non-small cell lung cancer (NSCLC), and to analyze the relationship between MIC-1 and clinical pathological factors. Results MIC-1 was expressed in advanced non-small cell lung cancer tissues. The positive expression rate was correlated with clinical stage. Conclusion MIC-1 can be used as a biomarker to evaluate the occurrence and development of elderly patients with advanced non-small cell lung cancer and provide the basis for finding a new treatment for elderly patients with advanced non-small cell lung cancer.