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目的:探讨温州地区女性不孕症患者解脲支原体(UU)和沙眼衣原体(Ct)的检出率、治疗转阴与妊娠效果。方法:选取女性不孕患者500例、配偶500例,设为观察组,其中原发性不孕426例、继发性不孕74例;选取健康已婚生育妇女50例、已婚育男性50例,设为对照组。采集女性宫颈分泌物、男性精液,检测UU、Ct水平。选用敏感抗生素治疗,观察UU和/或Ct转阴率;随访1年,观察妊娠率。结果:不孕症妇女UU、Ct、(UU+Ct)阳性率分别为41.2%、31.6%、16.2%,女性不孕症患者UU和/或Ct阳性率为89.0%,其配偶UU和/或Ct阳性率为62.0%,均高于对照组(P<0.05或P<0.01)。治疗1～3个疗程后,UU和/或Ct转阴率为81.0%;转阴患者1年内妊娠率为39.3%,高于未转阴患者(P<0.01)。结论:温州地区女性不孕症患者UU和/或Ct检出率较高,UU和/或Ct感染与不孕不育关系密切,通过规范的治疗,可获得较高的UU和/或Ct转阴率和妊娠率。
Objective: To investigate the detection rate of UU and Ct in female infertility patients in Wenzhou area, and to evaluate the effect of negative conversion and pregnancy. Methods: 500 infertile women and 500 spouses were selected as observation group, including 426 cases of primary infertility and 74 cases of secondary infertility. Fifty healthy married women and 50 male married men For example, set as a control group. Female cervical secretions collected, male semen, detection of UU, Ct levels. Select the treatment of sensitive antibiotics to observe the UU and / or Ct negative conversion rate; follow-up 1 year, observe the pregnancy rate. Results: The positive rates of UU and Ct, UU and Ct in infertile women were 41.2%, 31.6% and 16.2% respectively. The positive rate of UU and / or Ct in female infertility patients was 89.0% The positive rate of Ct was 62.0%, all higher than that of the control group (P <0.05 or P <0.01). After 1 to 3 courses of treatment, the negative rate of UU and / or Ct was 81.0%. The negative pregnancy rate of negative patients was 39.3% in one year, which was higher than that in patients without negative conversion (P <0.01). Conclusion: The prevalence of UU and / or Ct in women with infertility is high in Wenzhou. UU and / or Ct infection is closely related to infertility. Through standard treatment, higher UU and / or Ct Yin rate and pregnancy rate.