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病例要求:诊断明确并经2名以上血液病理委员会成员审核;伴有三系血细胞明显低,需反复输血者;初治者或经切脾、化疗(包括干扰素)治过者。用药方法:去氧助间型霉素5mg/m~2连用3天、间隔4周,或连用2天、间隔2周。静脉注入,每1mg不少于2分钟。别嘌呤醇300mg,2次/日,预防高尿酸血症。总疗程9-27周不等。结果:受试者共37例,36例获不同疗效。最终选27例指标完备者统计,完全缓解(体征消失、外周血3系细胞基本正常、骨髓达缓解标准)16例、占59%;部分缓解(肿块及骨髓中毛细胞数缩小或减少50%,血中3系细胞上升50%)10例、占37%;
Case requirements: The diagnosis is clear and reviewed by two or more members of the Hematopoietic Pathology Commission; accompanied by markedly lower blood cell counts of the three lines requiring repeated blood transfusion; those who are initially treated or those who have undergone splenectomy and chemotherapy (including interferon). Medication: deoxy coformycin 5mg / m ~ 2 for 3 days, an interval of 4 weeks, or once every 2 days, an interval of 2 weeks. Intravenous injection, not less than 2 minutes per 1mg. Allopurinol 300mg, 2 times / day, prevent hyperuricemia. The total duration of 9-27 weeks range. Results: A total of 37 subjects, 36 patients were treated with different effects. In the final selection of 27 cases, 16 cases (59%) had complete remission (signs disappeared, peripheral blood 3-line cells were normal and bone marrow up to remission standard), and partial remission (the number of hair cells and bone marrow reduced or decreased by 50% , Blood 3 line cells increased by 50%) 10 cases, accounting for 37%;