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[目的]探讨减量的奈达铂(NDP)联合小剂量顺铂(DDP)及5-氟尿嘧啶(5-Fu)/叶酸治疗晚期食管癌的近期疗效及不良反应。[方法]NDP25mg/m2、DDP15mg/m2,静脉点滴,第1、8d,5-Fu300mg·m-2·d-1,24h持续微量泵静脉输注,d1~5和d8~12,与5-Fu同步应用叶酸片60mg/d,21~28d1个周期,2个周期后评价疗效。[结果]治疗周期中位值为4.5个周期,CR2例,PR14例,SD5例,PD5例,总有效率(CR+PR)为61.5%(16/26)。主要不良反应是骨髓抑制,无Ⅳ度骨髓抑制,非血液学毒性包括恶心、呕吐、口腔炎、肝肾毒性等均较轻。[结论]减量奈达铂(NDP)联合小剂量顺铂(DDP)、5-氟尿嘧啶(5-Fu)/叶酸治疗晚期食管癌疗效确切,安全性好。
[Objective] To investigate the short-term curative effect and adverse reactions of reduced NDP combined with low-dose cisplatin (DDP) and 5-Fu / folic acid in the treatment of advanced esophageal cancer. [Methods] NDP25mg / m2, DDP15mg / m2, intravenous drip, the first 1,8d, 5-Fu300mg · m-2 · d-1,24h continuous micro pump intravenous infusion, d1 ~ 5 and d8 ~ 12, Fu simultaneous application of folic acid tablets 60mg / d, 21 ~ 28d1 cycles, two cycles after the evaluation of efficacy. [Results] The median duration of treatment was 4.5 cycles. There were CR2, PR14, SD5 and PD5, and the total effective rate (CR + PR) was 61.5% (16/26). The main adverse reactions were myelosuppression, no grade IV myelosuppression, and non-hematologic toxicities including nausea, vomiting, stomatitis, and hepatorenal toxicity. [Conclusion] The treatment of advanced esophageal cancer with NDP and DDP, 5-Fu / folate is effective and safe.