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目的:探讨薏苡仁甘油三脂注射液联合替吉奥化疗治疗晚期胰腺癌的免疫调节功能及对生存的影响。方法:67例局部晚期的胰腺癌随机分为两组。A组:薏苡仁甘油三脂注射液(100ml/d)联合替吉奥治疗6周期;B组:单药替吉奥治疗6周期。分别测定治疗前后CD3、CD4、CD8、CD4/CD8的值。结果:CD4+、CD4+/CD8+、NK细胞治疗后比治疗前显著提高(P<0.05),A组中位生存期13.2个月,B组12.3个月(P﹤0.05)。结论:薏苡仁甘油三脂注射液能提高晚期胰腺癌患者的免疫能力,提高患者中位生存期。
Objective: To investigate the immunomodulatory function of Coix Seed and Triglyceride Injection in combination with TIGO for the treatment of advanced pancreatic cancer and its effect on survival. Methods: 67 cases of locally advanced pancreatic cancer were randomly divided into two groups. Group A: Yiyiren triglyceride injection (100ml / d) combined with tegaserod 6 cycles; Group B: single-agent treatment for 6 cycles. The values of CD3, CD4, CD8, CD4 / CD8 before and after treatment were measured respectively. Results: The CD4 +, CD4 + / CD8 + and NK cells were significantly increased after treatment (P <0.05). The median survival time in group A was 13.2 months and that in group B was 12.3 months (P <0.05). Conclusion: Yiyiren triglyceride injection can improve the immune capacity of patients with advanced pancreatic cancer and improve the median survival time.