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最初认为干扰素是许多病毒感染后立即产生的一种抗病毒因子,以后发现除抗病毒外,干扰素还抑制细胞的分裂,增强细胞表面抗原的表达,促进NK 细胞的细胞毒活性,调节淋巴细胞和巨噬细胞的几种免疫功能。近年来,干扰素对调节培养细胞的增殖、分化和减慢动物和人肿瘤细胞生长的功能已引起人们的关注。目前,对细胞原癌基因(Cellular Proto-oncogenes)在调节细胞增殖及转化或表型恶化的表达方面的认识已提高到干扰素能否调节靶细胞原癌基因(如C-myc 和C-Ha-ras)的表达问题,从而对干扰素的抗癌作用机理进行着深入的探讨。
Interferon was originally thought to be an antiviral factor produced immediately after many viral infections. It was later discovered that in addition to antiviral, interferon also inhibits cell division, enhances the expression of cell surface antigens, promotes the cytotoxic activity of NK cells, and regulates lymphoid cells. Several immune functions of cells and macrophages. In recent years, interferon has attracted people’s attention to regulate the proliferation and differentiation of cultured cells and to slow the growth of tumor cells in animals and humans. At present, the understanding of cellular proto-oncogenes in regulating cell proliferation and expression of transformation or phenotypic deterioration has been raised to whether interferon can regulate target cell proto-oncogenes (such as C-myc and C-Ha The expression of -ras), thus the in-depth discussion of the anti-cancer mechanism of interferon.