论文部分内容阅读
目的：确定硒酸酯多糖（κ硒卡拉胶）胶囊在正常人体的药代动力学。方法：健康自愿者分为两组，一组餐前分别ｐｏ硒酸酯多糖１０，３０，５０和１００ｍｇ，另一组餐后ｐｏ５０ｍｇ，于服药前及服药后不同时间取血，用极谱法分别测定血硒含量。结果：血硒达峰时间（Ｔｐｅａｋ）４～５ｈ，消减半衰期约２１～２６ｈ。各剂量血药峰浓度（Ｃｍａｘ）及曲线下面积（ＡＵＣ）随剂量的递增而增加；而达峰时间及其他各常数Ｋｅ、Ｋａ、ｔ１／２（Ｋａ）、ｔ１／２（Ｋｅ）等均接近。进食对正常人体药代动力学无明显影响。给药剂量为１０，３０，５０，１００ｍｇ时，９６ｈ内药物随尿的总排泄率分别为４１．１０％，３７．４０％，３８．８４％和３４．７８％（Ｐ＞０．０５）。结论：药代动力学模型为一室模型，由肾脏经尿排泄是重要途径之一
Objective: To determine the pharmacokinetics of selenate polysaccharide (κ-seleno-carrageenan) capsule in normal human. Methods: Healthy volunteers were divided into two groups: one group each received 30, 30, 50 and 100 mg of selenate polysaccharide, and the other group received 50 mg of po 50 mg after meals. Blood samples were obtained before and after taking the drug by polarography Blood selenium levels were measured. Results: The blood peak time (Tpeak) 4 ~ 5h, half-life reduction of about 21 ~ 26h. The peak plasma concentration (Cmax) and the area under the curve (AUC) of each dose increased with the increase of dose, while the peak time and other constants Ke, Ka, t1 / 2 (Ka), t1 / 2 Close to Eating on the normal human pharmacokinetics no significant effect. The total excretion rate of drug in urine within 96h after administration was 41.10%, 37.40%, 38.84% and 34.78% (P> 0.05) at doses of 10, 30, . Conclusions: The pharmacokinetic model is a one-compartment model, which is one of the important ways of urinary excretion from the kidney