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多糖类物质作为赋形剂在药物制剂中已被广泛使用,多糖结构中包含了多种活性基团如羟基、羧基、氨基等,具有良好的亲水性、生物可降解性以及生物安全性,使其在聚合物-药物轭合物的构建中成为理想的载体材料.目前天然的多糖大分子及其衍生物作为药物载体的研究方兴未艾,以多糖为载体的聚合物-药物轭合物在定位或靶向给药、组织工程、生物黏附等领域也备受关注.本文以天然多糖-药物轭合物的研究现状为切入点,总结归纳了多糖-药物轭合物的设计与构建途径,介绍了其在药物传递中的应用,讨论并分析了多糖在轭合物体系中的角色和发挥的作用,对以多糖为载体的聚合物-药物轭合物发展的方向予以了讨论.
Polysaccharides as excipients have been widely used in pharmaceutical preparations. The polysaccharides structure contains a variety of active groups such as hydroxyl, carboxyl, amino, etc., with good hydrophilicity, biodegradability and biosafety , Making it an ideal carrier material in the construction of polymer-drug conjugates.Nowadays, studies on natural polysaccharide macromolecules and their derivatives as drug carriers are in the ascendant, with polysaccharide-supported polymer-drug conjugates at Targeting or targeted drug delivery, tissue engineering, bioadhesion, etc. In this paper, the current research status of natural polysaccharide-drug conjugate is taken as an entry point, the design and construction of polysaccharide-drug conjugate are summarized, The application of polysaccharide in drug delivery system was introduced. The role of polysaccharide in conjugate system was discussed and analyzed. The development of polysaccharide - drug conjugate was discussed.