论文部分内容阅读
目的:探讨人表皮生长因子-2(human epidermal growth factor-2,HER-2)与血管内皮生长因子-C(vascu-lar endothelial growth factor C,VEGF-C)、葡萄糖转运蛋白-1(glucose transporter,GLUT-1)在乳腺浸润性导管癌(invasiveductal carcinoma,IDC)淋巴结转移中的表达情况。方法:分析乳腺浸润性导管癌新鲜标本78例,其中无淋巴结转移者40例,出现淋巴结转移者38例,应用免疫组织化学法分析两组中HER-2、VEGF-C、GLUT-1表达情况,以及在不同分级的乳腺癌中的表达情况。结果:无淋巴结转移组与淋巴结转移组HER-2、VEGF-C、GLUT-1的表达均有统计学差异(P<0.05)。肿瘤分级Ⅱ级的淋巴结转移与非转移组HER-2、GLUT-1及VEGF-C表达水平,具有统计学差异(P<0.05或P<0.01)。结论:HER-2、GLUT-1及VEGF-C在乳腺浸润性导管癌淋巴结转移中发挥重要作用,不同肿瘤分级表达水平不同。
Objective: To investigate the relationship between HER-2 and VEGF-C, glucose transporter-2 (VEGF) , GLUT-1) in lymph node metastasis of invasive ductal carcinoma (IDC). Methods: A total of 78 specimens of fresh invasive ductal carcinoma of the breast were analyzed. Forty-eight cases without lymph node metastasis and 38 cases with lymph node metastasis were studied. The expressions of HER-2, VEGF-C and GLUT-1 in the two groups were analyzed by immunohistochemistry , As well as in different grading of breast cancer expression. Results: The expressions of HER-2, VEGF-C and GLUT-1 in non-lymph node metastasis group and lymph node metastasis group were significantly different (P <0.05). The levels of HER-2, GLUT-1 and VEGF-C in lymph node metastasis and non-metastasis group with grade Ⅱ were significantly different (P <0.05 or P <0.01). Conclusion: HER-2, GLUT-1 and VEGF-C play an important role in lymph node metastasis of invasive ductal carcinoma in breast. The expression levels of different grades of tumors are different.