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CD4+CD25+调节性T细胞(CD4+CD25+Treg)是维持机体免疫耐受的一种重要因素。它组成性表达IL-2受体α链(CD25),主要的功能是抑制自身反应性T细胞的活化和功能,调节机体对抗原的免疫应答,从而使机体避免发生自身免疫病。近年来研究表明,Treg也可能通过相同的机制削弱机体的抗肿瘤效应。Treg介导的免疫抑制是肿瘤逃逸的原因之一。针对Treg进行肿瘤免疫治疗是一项可行的策略。
CD4 + CD25 + regulatory T cells (CD4 + CD25 + Treg) is an important factor in maintaining immune tolerance. Its constitutive expression of IL-2 receptor alpha chain (CD25), the main function is to inhibit the activation and function of autoreactive T cells, regulate the body’s immune response to the antigen, so that the body to avoid the occurrence of autoimmune diseases. In recent years, studies have shown that Treg may also weaken the body’s anti-tumor effect through the same mechanism. Treg-mediated immunosuppression is one of the causes of tumor escape. Tumor immunotherapy for Treg is a viable strategy.