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磁共振波谱(magnetic resonance spectroscopy,MRS)及相关的磁共振波谱成像(magnetic resonance spectroscopy imaging,MRSI)广泛用于非侵入性评价临床和临床前研究的脑物质代谢。氢质子磁共振波谱(1H-MRS)是一种可无创地测量脑内神经化学物质的技术。1H-MRS已被应用于精神类疾病患者的活体病理生理研究。其中前额皮层(prefrontal cortex,PFC)在精神类疾病中起到重要作用。抑制性神经递质氨基丁酸(γ-aminobutyric acid,GABA)是中枢神经系统中最重要的神经递质,对机体的功能具有重要的调节作用。定量检测精神疾病患者PFC中的GABA水平,有望阐明此类疾病的病理生理及发病机制。本文从人类PFC的解剖功能以及
Magnetic resonance spectroscopy (MRS) and related magnetic resonance spectroscopy imaging (MRSI) are widely used to noninvasively assess brain substance metabolism in both clinical and preclinical studies. Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive technique for measuring neurochemicals in the brain. 1H-MRS has been applied to in vivo pathophysiology of patients with psychiatric disorders. Among them, prefrontal cortex (PFC) plays an important role in mental diseases. The inhibitory neurotransmitter GABA is the most important neurotransmitter in the central nervous system and plays an important regulatory role on the function of the body. Quantitative detection of mental disorders in patients with PFC GABA levels, is expected to clarify the pathophysiology of such diseases and pathogenesis. This article from the anatomical function of human PFC as well