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目的探讨河南汉族人群内皮细胞性一氧化氮合酶(eNOS)基因内含子4可变性重复序列(VN-TR)的多态性与缺血性脑血管病(ICVD)的关系。方法应用聚合酶链反应(PCR)技术,检测488例缺血性脑血管病患者的基因型,并与对照组比较。结果缺血性脑血管病组eNOS基因ab基因型的频率(18.4%)明显高于对照组(13.57%),a等位基因的频率(11.5%)也明显高于对照组(7.7%),差异均有显著性(P<0.05)。结论 eNOS基因ab基因型与缺血性脑血管病有相关性,等位基因a可能是缺血性脑血管病的危险因素。
Objective To investigate the relationship between the polymorphism of intron 4 variable repeat (VN-TR) of endothelial nitric oxide synthase (eNOS) gene and ischemic cerebrovascular disease (ICVD) in Henan Han population. Methods The genotypes of 488 patients with ischemic cerebrovascular disease were detected by polymerase chain reaction (PCR), and compared with the control group. Results The frequency of eNOS gene ab genotype (18.4%) in ischemic cerebrovascular disease group was significantly higher than that in control group (13.57%), and the frequency of a allele (11.5%) was also significantly higher than that in control group (7.7%). The difference was significant (P <0.05). Conclusion eNOS gene ab genotype is associated with ischemic cerebrovascular disease, allele a may be risk factors for ischemic cerebrovascular disease.