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胰岛素对机体调节糖、脂肪、蛋白质等代谢,尤其对维持血糖的正常浓度起着重要作用,临床上检测其含量具有一定的应用价值。1960年Yalow和Berson首先应用RlA测定病人血浆中胰岛素含量,1963年国内建立了胰岛素的RIA,1965年我国在世界上首先人工合成具有生物活性的结晶牛胰岛素。近年来,随着胰岛素及其抗体RIA的临床应用并深入研究探讨,对于糖尿病患者的诊断、分型、指导治疗,非糖尿病患者对胰岛素的影响等方面,取得一些进展,本文就此作一综述。 一、鉴别诊断IDDM、NIDDM糠尿病病人:糖尿病是世界各国一种常见多发性内分泌代谢病,且
Insulin on the body regulate sugar, fat, protein and other metabolism, in particular, to maintain the normal concentration of blood glucose plays an important role in the clinical testing of its content has a certain value. In 1960, Yalow and Berson first used RlA to measure the plasma insulin concentration in patients. In 1963, RIA was established in China. In 1965, China first synthesized the bioactive bovine insulin in the world. In recent years, with the clinical application of insulin and its antibody RIA and in-depth study and discussion, some progress has been made in the diagnosis, typing, guiding therapy, and the impact of non-diabetic patients on insulin. This article reviews this issue. First, differential diagnosis IDDM, NIDDM patients with diabetes mellitus: diabetes mellitus is a common multiple endocrine and metabolic diseases in the world, and