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１概述 早在５０多年前，Ｈｕｇｇｉｎｓ和 Ｈｏｄｇｅｓ就提出雄激素对前列腺癌生长有显著的调节作用［１］。通过雄激素去势或在雄激素受体水平阻断雄激素而进行的内分泌治疗，是晚期前列腺癌患者的必然选择，以症状的消失或血清前列腺特异性抗原（ＰＳＡ）水平的下降为依据?
1 Overview As early as 50 years ago, Huggins and Hodges proposed that androgen has a significant regulatory effect on the growth of prostate cancer [1]. Endocrine therapy by androgen deprivation or androgen blockade at the androgen receptor level is an inevitable choice for patients with advanced prostate cancer and is based on the loss of symptoms or the reduction of serum prostate-specific antigen (PSA) levels?