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目的:探讨慢性乙型病毒性肝炎(慢乙肝)患者血清转化生长因子-β1(transforming growth factor-β1,TGF-β1)水平与肝纤维化、HBVDNA载量的关系。方法:检测116例慢乙肝(慢乙肝组)患者和60名正常人(对照组)的血清TGF-β1、4项肝纤维化指标[透明质酸、层粘连蛋白、Ⅳ型胶原、Ⅲ型前胶原],以及HBVDNA载量,并作比较。结果:与对照组比较,慢乙肝组的血清TGF-β1水平、4项肝纤维化指标升高,病情严重程度不同的慢乙肝患者的TGF-β1水平及4项肝纤维化指标均高于对照组(P<0.05～0.01),上述指标的增高水平与病情严重程度呈正比,且TGF-β1与4项肝纤维化指标呈正相关(r值分别为0.629、0.586、0.622、0.618,均为P<0.01)。慢乙肝患者的TGF-β1水平与HBVDNA载量呈正比。结论:慢乙肝患者血清TGF-β1水平与其病情严重程度、肝纤维化指标及HBVDNA载量呈正比,检测慢乙肝患者的血清TGF-β1水平有助于判断其肝纤维化程度和病毒复制的活跃程度。
Objective: To investigate the relationship between the serum levels of transforming growth factor-β1 (TGF-β1) and liver fibrosis and HBVDNA load in patients with chronic hepatitis B (chronic hepatitis B). Methods: The serum levels of TGF-β1, IL-4 and IL-6 in 116 patients with chronic hepatitis B (chronic hepatitis B) and 60 healthy controls (control group) Collagen], and HBVDNA load, and for comparison. Results: Compared with the control group, serum levels of TGF-β1 and four markers of liver fibrosis in chronic hepatitis B group were significantly higher than those in control group, and the levels of TGF-β1 and four liver fibrosis markers in chronic hepatitis B patients with different severity of illness were higher than those in control group Group (P <0.05-0.01). The level of these indexes was in direct proportion to the severity of the disease, and there was a positive correlation between TGF-β1 and four indexes of hepatic fibrosis (r values were 0.629,0.586,0.622,0.618 respectively, P <0.01). TGF-β1 levels in patients with chronic hepatitis B are directly proportional to the HBV DNA load. Conclusion: The serum level of TGF-β1 in patients with chronic hepatitis B is positively correlated with the severity of the disease, liver fibrosis index and HBVDNA load. Detecting serum TGF-β1 level in patients with chronic hepatitis B is helpful to determine the degree of liver fibrosis and viral replication degree.