目的检测VEGF-C及其受体VEGFR-3(flt-4)在宫颈病变组织中的表达,探讨二者在宫颈癌淋巴管生成及淋巴结转移中的作用。方法收集临床手术切除的宫颈癌组织86例,应用VEGF-C与flt-4多克隆抗体进行SP法免疫组化染色。结果VEGF-C与flt-4表达之间呈明显正相关,即随着VEGF-C表达强度的增加flt-4阳性淋巴管数也明显增加。结论VEGF-C在宫颈癌癌变过程中起一定的促进作用,VEGF-C/flt-4调控系统与宫颈癌组织的淋巴管生成及肿瘤细胞的淋巴道转移密切相关。 Objective To investigate the expression of VEGF-C and its receptor VEGFR-3 (flt-4) in cervical lesions and to explore the roles of VEGF-C and lymphangiogenesis in cervical cancer. Methods Totally 86 cases of clinically resected cervical cancer tissues were collected and immunohistochemically stained with polyclonal antibody against VEGF-C and flt-4. Results There was a positive correlation between VEGF-C and flt-4 expression, that is, the number of flt-4 positive lymphatic vessels also increased significantly with the increase of VEGF-C expression. Conclusion VEGF-C plays a role in promoting the carcinogenesis of cervical cancer. The regulatory system of VEGF-C / flt-4 is closely related to lymphangiogenesis and lymphatic metastasis of cervical cancer.