凝血酶原是由肝脏合成的维生素K依赖性凝血因子,其前体蛋白的谷氨酸残基羧化障碍或羧化不全可形成异常凝血酶原。异常凝血酶原检测是估价维生素K缺乏的敏感方法,也是监测维生素K拮抗剂的有效指标。近来发现,它对肝癌有相对特异性,对肝癌的诊断和鉴别诊断有一定价值。本文对异常凝血酶原形成的生化基础,理化特性,检测方法及其对肝癌的诊断价值作一综述。 Prothrombin is a vitamin K-dependent clotting factor synthesized by the liver, and its precursor protein may be abnormal prothrombin due to carboxylation disorder or carboxylation of glutamate residues. Abnormal prothrombin testing is a sensitive method of assessing vitamin K deficiency and is a valid indicator of vitamin K antagonist monitoring. Recently found that it has a relative specificity of liver cancer, liver cancer diagnosis and differential diagnosis of some value. This article summarizes the biochemical basis, physical and chemical properties, detection methods and diagnostic value of abnormal prothrombin on liver cancer.