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严重的原发性高血压伴低肾素者,单用巯甲丙脯酸效果不佳,加用利尿剂后奏效;而加用β阻滞剂则不然。为此作者给24例中等到严重的无并发症的原发性高血压病人,应用巯甲丙脯酸加氢氯噻嗪或心得安,观察其降压效果、体重、血浆肾素活性(PRA)和醛固酮的变化。第1组为16(男9,女7)例,平均年龄52岁,接受巯甲丙脯酸加氢氯噻嗪治疗。巯甲丙脯酸每日服3次,第1周每次剂量为25mg,第2周50mg,第3周100mg,第4周150mg。第5周加用氢氯噻嗪25mg每日2次。其中11例舒张压仍大于95mmHg 者,氢氯噻嗪加至50mg 每日2次。
Severe primary hypertension with low renin, single captopril alone ineffective, plus diuretics after the effect; plus beta blockers are not. To this end, 24 patients with moderate to severe non-complication of essential hypertension, the application of captopril hydrochlorothiazide or propranolol, observed antihypertensive effect, body weight, plasma renin activity (PRA) and aldosterone The change. Group 1 was 16 (9 males and 7 females) with a mean age of 52 years and was treated with captopril plus hydrochlorothiazide. Captopril daily 3 times a day, the first week of each dose of 25mg, 2 weeks 50mg, 3 weeks 100mg, 4 weeks 150mg. Week 5 plus hydrochlorothiazide 25mg twice daily. Eleven patients had a diastolic blood pressure greater than 95 mmHg, and hydrochlorothiazide was added to 50 mg twice daily.