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亚硒酸氢钠（ＮａＨＳｅＯ３）的致突变和抗突变作用尚无定论，本文应用稍加修改的ＳＯＳ／Ｕｍｕ显色试验对其这方面的作用作了研究。结果发现，ＮａＨＳｅＯ１剂量在０．６７－８．００ｍｇ／ｍｌ范围内，无Ｓ９时，ＳＯＳ反应的诱导率（Ｒ）有剂量一效应关系，最低诱导剂量为１．８６ｍｇ／ｍｌ：存在Ｓ９时，各剂量组的Ｒ值均接近于１。结果还揭示ＮａＨｓｅＯ３能明显抑制丝裂霉素Ｃ（ＭＭＣ）诱发的β－半乳糖苷酶（ＢＧａｓｅ）活性，其剂量－效应曲线呈抛物线。据此曲线的方程式，估得２０％、４０％和６０％抑制的剂量分别为０．４８，１．３７和３．２１ｍｇ／ｍｌ；最大有作用剂量为３．５８ｍｇ／ｍｌ，其抑制率为６１％，这些结果表明：ＮａＨＳｅＯ３可能是ＳＯＳ的直接诱导剂，同时又是ＭＭＣ诱发ＳＯＳ反应的强抑制刑，且可在无明显诱导作用的剂量（＜１．８６ｍｇ／ｍｌ）下，即可有抗ＭＭＣ的诱导作用。
The mutagenesis and anti-mutagenic effects of sodium selenite (NaHSeO3) have not been elucidated yet. In this paper, the effect of this modification in SOS / Umu chromogenic assay was studied. The results showed that the dosage of NaHSeO1 was in the range of 0.67-8.00mg / ml, and the SOS induction rate (R) had dose-effect relationship without S9 with the lowest induction dose of 1.86mg / ml. In the presence of S9, The R values for each dose group were close to 1. The results also revealed that NaHseO3 significantly inhibited mitomycin C (MMC) induced β-galactosidase (BGase) activity, the dose-response curve of the parabola. According to the equation of the curve, it is estimated that the doses of 20%, 40% and 60% inhibition are 0.48, 1.37 and 3.21 mg / ml respectively; the maximum effective dose is 3.58 mg / ml and the inhibition rate is 61%. These results indicate that NaHSeO3 may be a direct inducer of SOS and a strong inhibitor of SOS induced by MMC, and may be administered at a dose of less than 1.86 mg / ml without significant induction (<1.86 mg / ml) Anti-MMC induction.