目的:探讨不同保守治疗方法对于异位妊娠的近远期疗效及不良反应。方法:血管性放射介入治疗(A组),腹腔镜保守手术治疗(B组),氨甲蝶呤(methotrexate,MTX)肌肉注射治疗(C组)应用于异位妊娠保守治疗,观察其临床疗效及远期妊娠状况。结果:A组、B组、C组治疗后血人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)转阴时间分别为(18.5±8.7)d、(6.4±2.2)d、(19.5±8.3)d,治愈率分别为97.0%、96.7%、90.0%,术后3个月子宫输卵管碘油造影患侧输卵管通畅率分别为83.3%、40.0%、72.0%,术后1年宫内妊娠率分别为66.7%、37.9%、59.3%,术后1年患侧再次异位妊娠率分别为3.3%、6.9%、3.7%。成功组与失败组治疗前血HCG及包块直径无明显差异(P>0.05),失败组血HCG均>3 000 mIU/ml,与成功组相比有统计学差异(P<0.05)。结论:血管性放射介入治疗治愈率高,创伤小,远期妊娠结果较好;腹腔镜保守性手术成功率高,术后血HCG下降迅速;药物治疗组适用于血HCG<3 000 mIU/ml,费用较低。 Objective: To explore the short-term efficacy and adverse reactions of different conservative treatment methods for ectopic pregnancy. Methods: Vascular radiotherapy (group A), laparoscopic conservative surgery (group B) and methotrexate (MTX) intramuscular injection (group C) were used in conservative treatment of ectopic pregnancy, and the clinical efficacy was observed And long-term pregnancy status. Results: After treatment, the time of human chorionic gonadotropin (HCG) in group A, group B and group C were (18.5 ± 8.7) d, (6.4 ± 2.2) d, (19.5 ± 8.3) d, the cure rates were 97.0%, 96.7% and 90.0% respectively. The tubal patency rates of the tubal lipiodol angiography were 83.3%, 40.0% and 72.0% respectively at 3 months after operation, and the intrauterine pregnancy rates at 1 year after operation were 66.7%, 37.9% and 59.3% respectively. The rate of ectopic pregnancy after one year was 3.3%, 6.9% and 3.7% respectively. There were no significant differences in HCG and mass diameter between the two groups before and after treatment (P> 0.05). The blood HCG in the failed group was> 3 000 mIU / ml, which was significantly different from that in the successful group (P <0.05). Conclusion: The high cure rate, small trauma and long-term pregnancy result are better in interventional therapy of vascular radiotherapy. The success rate of laparoscopic conservative surgery is high and the blood HCG declines rapidly postoperatively. The drug treatment group is suitable for blood HCG <3000 mIU / ml , The cost is lower.