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我们利用双抗体夹心法对６５例慢性乙型肝炎（简称慢乙肝）虚实证患者（其中虚证３１例、实证３４例）及２０例正常对照者的血清ＴＮＦ含量进行了检测．并观察用小柴胡汤按虚、实证辨证加减治疗对ＴＮＦ及肝功能的影响。结果表明：１．慢乙肝患者血清ＴＮＦ含量较正常人显著升高（Ｐ＜０．００１）；２．慢乙肝虚、实证患者血清ＴＮＦ含量均较正常人显著升高（Ｐ＜０．００１），但虚证患者血清ＴＮＦ含量较实证低（Ｐ＜０．００２），提示慢乙肝虚、实证患者存在免疫状态的差别；３．慢乙肝患者血清ＴＮＦ含量与肝损害程度呈正相关（ｒ＝０．２６７，Ｐ＜０．０５），提示ＴＮＦ可作为衡量病情轻重的一个客观指标；４．用小柴胡汤按虚、实证辨证加减治疗慢乙肝虚、实证患者后，血清ＴＮＦ含量及肝功能均较治疗前改善（Ｐ＜０．００１或Ｐ＜０．０１），提示小柴胡汤是治疗慢乙肝的有效方剂。
We used the double-antibody sandwich method to detect the serum TNF level in 65 cases of chronic hepatitis B (abbreviated as chronic hepatitis B) deficiency syndrome (31 cases of deficient, 34 cases of positive) and 20 cases of normal controls. Observe the effects of Xiao Chai Hu Tang Deficiency and empirical syndrome differentiation treatment on TNF and liver function. The results show that: 1. The serum level of TNF in patients with chronic hepatitis B was significantly higher than that in normal controls (P<0.001). The levels of serum TNF in patients with chronic hepatitis B deficiency and positive patients were significantly higher than those in normal subjects (P<0.001), but the levels of serum TNF in patients with asthenia syndrome were lower than those in the empirical group (P<0.002), suggesting that chronic hepatitis B deficiency and positive patients existed. Differences in immune status; 3. The serum level of TNF in patients with chronic hepatitis B was positively correlated with the degree of liver damage (r=0.267, P<0.05), suggesting that TNF can be used as an objective measure of severity of disease; After treatment with Xiaochaihutang according to deficiency and empirical syndrome differentiation and treatment of chronic hepatitis B deficiency and positive patients, serum TNF content and liver function were improved compared with before treatment (P<0.001 or P<0.01), suggesting that Xiaochaihutang is An effective formula for treating chronic hepatitis B.