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本文介绍了喃氟啶(FT-207)九种制剂通过不同给药途径的生物利用度,有非常显著性的差异(P<0.01),吸收速度和吸收程度的顺序是栓剂>胶囊>片剂。五种栓剂直肠给药后,达峰时间约比口服制剂快一倍,血药浓度的峰值比口服制剂高一倍左右,栓剂的吸收速度常数也比口服制剂大1～2倍。栓剂的生物利用度与静脉注射的相近,比口服制剂大。说明FT-207栓剂直肠吸收比口服制剂吸收为优。
The bioavailability of nine preparations of FT-207 by different route of administration was introduced in this paper. There was a significant difference (P <0.01). The order of absorption rate and degree of absorption was suppository> capsule> tablet . After rectal administration of five suppositories, the peak time is about twice as fast as the oral formulation, and the peak value of the plasma concentration is about twice as high as that of the oral preparation. The suppository’s absorption rate constant is also 1 to 2 times larger than that of the oral preparation. The suppository bioavailability and intravenous injection of similar, larger than oral preparations. Description FT-207 suppository rectal absorption than oral absorption is better.