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先天性心脏病(congenital heart disease,CHD)是发病率最高的出生缺陷性疾病,是儿童时期最常见的心脏病,其中严重先天性心脏病(critical congenital heart disease,CCHD)约占1/4~([1])。在CHD自然病程及治疗过程中皆容易合并心肌损害,如何预防和治疗心肌损害、提高CHD综合治疗水平日益受到临床关注。1 CHD血流动力学异常与心肌损害临床根据左、右心及大血管之间分流情况,CHD分为左向右分流型、右向左分流型及无分流型三大类。
Congenital heart disease (CHD) is the highest incidence of birth defects, is the most common childhood heart disease, of which severe congenital heart disease (CCHD) accounts for about 1/4 ~ ([1]). In the natural course of CHD and the course of treatment are easy to merge myocardial damage, how to prevent and treat myocardial damage, improve the level of CHD comprehensive treatment is increasingly subject to clinical attention. 1 CHD hemodynamic abnormalities and myocardial damage according to the left and right heart and large blood vessels between the shunt, CHD is divided into left to right shunt, right to left shunt and no shunt three categories.