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目的：了解慢性肾功能不全患者不同病期血浆白细胞介素８（ＩＬ８）的含量及其临床意义。方法：用双抗夹心酶联免疫吸附法分别测定慢性肾功能不全患者不同病期血浆ＩＬ８含量，并与正常对照组比较。结果：慢性肾功能不全代偿期及氮质血症期患者血浆ＩＬ８略低于正常对照组，但差异无显著性（Ｐ均＞０．０５）。肾功能衰竭期患者血浆ＩＬ８含量显著低于正常对照组（Ｐ＜０．０１）。在慢性肾功能不全病程中，血浆ＩＬ８含量与血肌酐、尿素氮呈显著负相关（ｒ＝－０．５８，Ｐ＜０．０１；ｒ＝－０．５１，Ｐ＜０．０１）。结论：慢性肾功能不全患者肾功能衰竭期机体全身免疫功能低下，急性炎症反应减弱。
Objective: To understand the content of plasma interleukin 8 (IL8) in patients with chronic renal insufficiency and its clinical significance. Methods: The levels of plasma IL-8 in patients with chronic renal insufficiency at different stages were determined by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) and compared with that of the normal control group. Results: Plasma IL8 in compensated patients with chronic renal insufficiency and azotemia was slightly lower than that in the normal control group, but the difference was not significant (all P> 0.05). Plasma IL8 levels in patients with renal failure were significantly lower than those in the normal control group (P <0.01). In the course of chronic renal insufficiency, the level of plasma IL8 was negatively correlated with serum creatinine and blood urea nitrogen (r = -0.58, P <0.01; r = -0.51, P <0.01). Conclusion: In patients with chronic renal insufficiency renal dysfunction, systemic immune function is low, acute inflammatory response weakened.