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目的探讨血清血管内皮生长因子(vascular endothelia l growth factor,VEGF)及妊娠相关血浆蛋白A(preg-nancy-associated plasma protein-A,PAPP-A)在异位妊娠患者血清中的改变及其意义。方法收集57例正常早孕孕妇血清(孕龄为5-8周),92例异位妊娠患者血清,采用酶联免疫吸附技术(ELISA),分别检测血清VEGF及PAPP-A水平。结果与正常妊娠组比较,同孕龄异位妊娠患者VEGF水平均明显升高,差别具有显著意义(P<0.05);PAPP-A与同孕龄正常宫内孕比较,在孕龄<7周时差异不明显(P>0.05),≥7周时明显降低,差别具有显著意义(P<0.05)。结论在异位妊娠的早期诊断中,血清VEGF和PAPP-A相比,VEGF是更为敏感的指标。
Objective To investigate the changes and significance of serum vascular endothelial growth factor (VEGF) and preg-nancy-associated plasma protein-A (PAPP-A) in patients with ectopic pregnancy. Methods The serum of sera (5-8 weeks gestational age) and 92 cases of ectopic pregnancy were collected from 57 normal pregnant women. Serum levels of VEGF and PAPP-A were detected by enzyme linked immunosorbent assay (ELISA). Results Compared with the normal pregnancy group, the VEGF level in ectopic pregnancy patients with the same gestational age were significantly increased, the difference was significant (P <0.05); PAPP-A with gestational age less than 7 weeks (P> 0.05). The difference was significant at ≥7 weeks (P <0.05). Conclusions In the early diagnosis of ectopic pregnancy, serum VEGF is a more sensitive marker than PAPP-A.