论文部分内容阅读
目的探讨脑损伤患者脑脊液和血液中肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)表达水平的变化及其临床意义。方法采用双抗体夹心ELISA方法测定脑损伤患者急性期内TNF-α、IL-6在脑脊液和血液中相对含量。结果 TNF-α、IL-6在脑损伤急性期有较高表达,与对照组相比有统计学意义,且脑脊液中的表达明显强于外周血液。结论受外伤应激,神经细胞和神经胶质细胞迅速动员机体免疫系统作出反应,产生大量保护性细胞因子,参与损伤局部组织的免疫反应。
Objective To investigate the changes of tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in cerebrospinal fluid and blood and their clinical significance. Methods The relative contents of TNF-α and IL-6 in cerebrospinal fluid (CSF) and blood in patients with brain injury during acute phase were determined by double antibody sandwich ELISA. Results TNF-α and IL-6 were highly expressed in the acute phase of brain injury, which was significantly higher than that in the control group. The expression of TNF-α and IL-6 in cerebrospinal fluid was significantly higher than that in peripheral blood. Conclusion By traumatic stress, nerve cells and glial cells rapidly mobilize the body’s immune system to respond to produce a large number of protective cytokines, involved in the injury of local immune response.