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目的观察人工泪液联合性激素对围绝经期白内障患者超声乳化术后泪膜功能恢复的影响。方法 64例接受白内障超声乳化联合人工晶状体植入术的围绝经期白内障患者随机分为对照组和实验组2组。对照组术后采用妥布霉素地塞米松点眼,实验组在此基础上联用人工泪液和性激素,观察两组患者术前及术后3、7、30、90d的干眼症状评分、基础泪液分泌试验(SIT)、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)情况。结果术后3、7、30、90d,实验组干眼症状评分、CFS评分均小于对照组,SIT试验和BUT较对照组长,差异有统计学意义(P<0.05)。结论围绝经期白内障超声乳化联合人工晶状体植入术患者术后早期使用人工泪液联合性激素治疗有利于泪膜恢复,改善干眼症。
Objective To observe the effect of artificial tears combined with sex hormones on the recovery of tear film after phacoemulsification in perimenopausal period. Methods 64 cases of perimenopausal cataract patients undergoing phacoemulsification and intraocular lens implantation were randomly divided into control group and experimental group. The control group was treated with tobramycin dexamethasone, and the experimental group was combined with artificial tears and sex hormones on the basis of this study. The scores of dry eye symptom at 3, 7, 30, 90 days before and after operation were observed. Tear secretion test (SIT), tear film break-up time (BUT), corneal fluorescein staining (CFS). Results At 3, 7, 30 and 90 days after operation, the scores of dry eye symptom and CFS in experimental group were lower than those in control group. The SIT and BUT were significantly higher than those in control group (P <0.05). Conclusions Peri-menopausal phacoemulsification combined with intraocular lens implantation in early postoperative patients with artificial tears combined with hormone therapy is conducive to tear film recovery and improve dry eye syndrome.